Van Gogh^TM

Current techniques for tissue evaluation take time, damage samples, and can produce inadequate assessments, resulting in prolonged procedures and the need for additional biopsies. These setbacks can delay diagnoses and impact patient treatment timelines. Aquyre Biosciences’ Van Gogh^TM addresses these challenges.

Powered by two proprietary technologies, including Dynamic Cell Imaging (DCI), Van Gogh can analyze any biopsy at a depth of 150μm below the tissue surface and measure intracellular and metabolic activity throughout. This process does not require any cutting or staining, leaving the sample unchanged for final pathology to accurately diagnose and perform next-generation sequencing (NGS). Using light, the cell shape, size, and activity are highlighted in a heatmap, making it easier to assess tissue adequacy.

Intended use: An FDA Class I in-vitro diagnostic medical device.

Dynamic Cell Imaging (DCI) enhances the cellular contrast by capturing the residual microscopic intracellular movements in freshly excised tissue which complements the morphological information provided by FFOCT, thus bringing Aquyre Biosciences images up to the histology level of detail and information richness.

The DCI technique consists in recording the time series of each voxel under examination during a few seconds and process them in order to extract characteristic features of the subcellular activity to be displayed. From a Fourier analysis of the time signal, the DCI RGB image is created where the blue channel corresponds to low frequency moving parts (< 0.5 Hz), the green channel displays medium frequency moving parts (0.5 to 5 Hz), and the red channel displays higher frequency moving parts (5 to 25 Hz). The signal intensity in each color channel reflects the dynamics amplitude in each corresponding frequency range.